This article offers a Spanish national perspective that contributes to European Responsible Research and Innovation (RRI) monitoring initiatives. National experts involved in gender and science and technology issues, such as policymakers, gender experts, research institutions, and equality associations, among others, have proposed indicators based on participatory decision-making techniques. The results include a complete set of 52 indicators and a reduced panel of 23 indicators—the highest-ranked ones—to monitor relevant aspects that should be measured in gender dimension from an RRI perspective: differential and asymmetric socialization and education, organizational culture, substantive representation, vertical segregation, work relations, visibility of women researchers, gender perspective in research contents, gender expertise enhancement, and resources. The results offer new indicators that differ from previous indicator panels at the European and Spanish levels in relation to those aspects that should be measured and the typology of indicators preferred. Differences suggest the need for a more nuanced debate on the purpose of indicators, and the need for national contributions to RRI and to the debate on gender perspective in EU policy. Finally, the article suggests some specific traits observed in Spain that might add to the debate on the content of an RRI gender perspective in an already developed gender policy.