Policy evaluation is a key issue in the policy cycle, despite it has not been deserved a careful attention, specially with respect to ex-post policy evaluation in peripheral European regions such as Valencia. Some evaluation methodologies seem to be useful in some cases but not in others, where the availability of data and infrastructures to carry out evaluation, lags clearly behind. This rises the issue of how to compare the results in the design and implementation of regional S&T policies across regions in Europe. Since evaluation, in any case, implies the measurement of some results and its comparison to a certain scale previously established, the research arena is opened to enquire on the design and implementation of comparable evaluation methodologies with relevant policy implications to be considered in the European Research Area. Many methodologies, are inspired on the design and development of indicators used to capture direct results of policy implementation. Others are inspired on the consideration of additionality as the main result pursued with the application of a policy. Here, we propose to study the evaluation of regional S&T policies regarding the efficiency of such policies. In this case, a study concerning the evaluation of the S&T policies implemented in the Spanish regions according to their efficiency levels will be a matter of interest. In order to achieve that goal the Data Envelopment Analysis (DEA) will be applied due to the advantages it offers in public studies.